28/05/2020 15:56:42 |
0 binh luận
T he results of Y90 radioembolization in treatment of hepatocellular carcinoma SUMMARY Background : Hepatocellular carcinoma (HCC) is aggressive primary malignancy of the liver that most commonly presents late in the disease course. As a result, the majority of patients are not candidates for curative therapies. Locoregional therapies including Yttrium-90 (Y-90) radioembolization play an important role in management of the vast majority of patients with HCC. Methods : Patients with unnresectable HCC (n=41) treated with Y-90 radioembolization from 2013 to 2016 were evaluated retrospectively. Data was abstracted from medical records including patient charts, laboratory data, and imaging. Results : The most common clinical toxicity among all patients was fatigue (58.5%). A clinical benefit, defined as patients achieving PR was seen in 95.13% of cases; was seen complete reponse (CR) in 4.87%. The mean overall survival from the time of diagnosis was 18.4 months. Conclutions : For patients with HCC, Y-90 radioembolization is a safe and well-tolerated procedure. Our experience suggests that a significant percentage of patients achieve clinical benefit including many with PR. Prospective, randomized data is required to compare radioembolization with other therapies including chemoembolization and systemic therapy with sorafenib. Keywords : Radioembolization, Yttrium-90 microspheres, SIR-spheres, Hepatocellular carcinoma, Transarterial radioembolization, SIRT.