SUMMARY Purpose: Evaluation the effectiveness of the extrahepatic arterial chemoembolization on treatment of hepatocellular carcinoma. Subjects and methods: There is a non-controlled prospective intervention study in HCC patients with tumors which had blood supply from extrahepatic arteries from July 2019 to August 2020 in Radiology center of Bach Hospital. Results: . Our study was performed on 56 patients including 48 men (85.7%) and 8 women (14.3%) who were diagnosed with HCC. The mean age were 58.29 ± 10,849 years old. The rate of successful approaching to the extrahepatic vessel branches was 83.05%. There were 2 patients (3.58%) had acute complications during and immediately after intervention. Special complications related directly to the extra-hepatic embolization were observed in 14 patients (25%). After an average of 2.25 ± 0.919 months of follow-up, 1 patient (1.8%) re-examined due to rupture of liver tumor, the remaining 55 patients (98.2%) were reexamined by appointment. The results of tumor response according to mRECIST with complete response, partial response, stable disease and progressive disease were 3.6%, 52.7%, 25.5%, and 18.2% respectively. Conclusion : The results of the extrahepatic arterial chemoembolization in our study had high rates of the successful approaching to the extrahepatic vessel branches, the intervention safety and the post-intervention tumor response. Key words: TACE, Extrahepatic artery supply to HCC