SUMMARY Purpose: To review some clinical features, characteristics of 18FDG uptake of tumors and lymph nodes on PET/CT in NSCLC patients with indications for radical surgery at Hanoi Oncology Hospital. Subjects and methods: 82 patients with primary NSCLC were taken with 18FDG PET/CT before surgery. Results: Right lung tumor 64.6%, left lung tumor 35.4%. The average size of the tumor was 2.6 ± 1.0 cm, the patient with lymph node (+) on PET/ CT had an average lung tumor size of 3.3 ± 0.9cm; larger than patients with N0 lymph nodes (p < 0.05). The mean SUVmax of lung tumors was 6.0 ± 4.5 and increased with tumor size (positive correlation, r=0.58). U ≤2cm, SUVmax = 4.1 ± 2.1. U >2-3cm, SUVmax = 5.3 ± 3.6 and U >3 -5cm, SUVmax = 8.3 ± 4.9. SUVmax increases with clinical disease stage and is higher in patients with positive lymph nodes on PET/CT. Conclusion: 18FDG PET/CT plays an important role in the diagnosis of NSCLC. SUVmax is a quantitative parameter related to tumor size, lymph node status and clinical disease stage. Keywords: NSCLC, 18FDG-PET/CT, SUVmax.

SUMMARY Background: Dynamic renal scan has become one of the most effective techniques to investigate the kidney parenchymal function, also the urine collecting and drainage system, in both adults and children. Compared with adults, it is the most commonly used test in children and accounts for more than half of the indications for nuclear medicine unit. In City Children's Hospital, dynamic renal scan has been implemented since the beginning of 2018 and initially showed its clearly role in facilitating the decision on treatment and follow-up strategy of pediatric patients. Therefore, we carry out this study to evaluate the results of dynamic renal scan application of the unit. Objective: To assess the results of application of dynamic renal scan with 99mTc-DTPA on pediatric patients in City Children's Hospital. Subject and method: We retrospectively examined data derived from 671 pediatric patients aged 01 month to 15 years in City Children’s Hospital who underwent at least 1 99Tc DTPA dynamic renal scan with diuretic challenge test from June 2018 to March 2022. The main purpose is to investigate some of the scintigraphic features related to Hydronephrosis in children and the prognostic factors of renal function loss. Results: There were a total of 740 performed scans, including 611 patients underwent once, 52 patients underwent twice, 7 patients underwent threetimes and 1 patient underwent fourtimes. Among them, there are 454 boys and 217 girls with a male/female ratio of 2/1. The age of the pediatric patients at the time of scanning varied, from 1 month to 15 years old. However, there is a clear dominant distribution for the group of patients under 5 years old, accounting for 516 cases (~69.7%%), which is more than 3 times the number for the group of patients aged 5 to 10 years and about 10 times for the group of patients over 10 years old, 175 cases (~23.7%) and 49 cases (~6.6%) respectively. Many different geographical locations in the country, where the patients come from, were noted. However the majority of cases live in Ho Chi Minh City, the number is 218 cases, accounting for ~30% of the total, followed by the west provinces and provinces from central region, as well as the Highlands area.*

SUMMARY Objective: We aimed to evaluate the effectiveness of early outcomes of PAE in treating 10 BPH patients with acute urinary retention. Method and results: in this prospective study approved by the institutional review board, a signed informed consent was obtained. There were ten patients with AUR due to BPH from 01/2021 to 12/2022. The patient's successful removal of the bladder catheter after 10-15 days. Postintervention 3 months, average evaluation of IPSS, Qol, PSA (ng/ml), and PV (cm3) decreased 58,48%; 76,03%; 80,95%; 29,97% (ultrasound) 31,75% (MRI); Qmax 12,46(ml/s), PVR 45,84(ml) Conclusion: PAE in patients with AUR due to BPH is safe and effective Keywords: Benign prostatic hyperplasia (BPH), Prostatic arterial embolization (PAE), Acute urinary retention (AUR)

SUMMARY Background: back pain and sciatica caused by disc herniation has a burden upon social activity. The newly minimally invasive technique, percutaneous Ozone (O2-O3) intradisal injection procedure has demonstrated safe and effective in long terms. Purpose : Evaluate the clinical effectiveness of intradiscal Ozone injection combining periradicular injection of Ozone and steroid under CT guidance for the treatment of lumbar disc herniation. Material and method: Prospective study, 100 patients symtomatic (lumbar pain, sciatica) with mild/moderate lunbar disc bulging or herniation on MRI. The patients were treated with intradiscal Ozone injection combining periradicular injection of Ozone and steroid under CT guidance. Clinical outcomes and MRI images were reviewed to evaluate at 3 months and 6 months. Results: The VAS score and the Oswestry Disability Index (ODI) before and after treatment 3months, 6 months were significant reduction. The mean improvement was 4.7 for VAS and 14 for ODI. All the procedures were technically successful. There were no adverse events associated with the treatment. Conclusion: Intradiscal injection Ozone treatment of herniated disc is an minimally invasive, easy, safe and effective procedure with low complications and side effects. Keywords: lumbar disc herniation, O3 injection

SUMMARY Purpose: To evaluate the diagnostic accuracy of magnetic resonance spectroscopy and dynamic contrast-enhanced (DCE) magnetic resonance perfusion for glioma grading. Materials and Methods: Fifteen patient confirmed pathological glioma who underwent MR spectroscopy and DCE in 3 Tesla MRI machine. The following parameters were used: Ktrans, Ve, Cho/NAA, Cho/Cre. The diagnostic accuracy for glioma grading was determined by ROC analysis. Results: There were 10 patients in the high-grade group and 5 patients in the low-grade group. Ktrans, Ve, Cho/NAA and Cho/Cre measures differed significantly between high and low-grade tumor. The AUC was 0.956 for Ktrans. Conclusion: Ktrans, Ve Cho/NAA and Cho/Cre parameters demonstrated to be useful for glioma grading. Keywords: Spectroscopy, DCE-MRI, glioma grading

SUMMARY Purpose: The study was conducted to describe image characteristics of prostate cancer on multidetector computed tomography (MDCT) and to determine the role of MDCT in patients with stage IV prostate cancer. Objectives and subjects: A cross-sectional study was performed on 45 patients at Huu Nghi Hospital from January 2017 to May 2023. All patients had pathologically proven prostate cancer, multi-parameter magnetic resonance imaging (mp-MRI), MDCT, and bone scan and were categorized as stage IV. Results: The mean age was 78.31±5.64 years, mean Total prostatespecific antigen (tPSA) concentration was 279.78 ng/ml, mean prostate volume was 45.20 ml. 60% of patients had extra-prostatic invasion, 66.7% had regional lymph node metastases; 40% of patients had distant lymph node metastasis; 46.7% had bone metastasis; 28.9% had distant metastasis to other organs. MDCT had good to very good concordance with MRI in evaluating local invasion and good concordance with bone scintigraphy in evaluating bone metastasis, with p <0.05. Conclusion: MDCT had a high value in assessing metastatic lesions in patients with stage IV prostate cancer, especially lung lesions. Whole-body MDCT is a useful alternative to MRI and PET/CT in evaluating metastatic lesions from prostate cancer. Keywords: Prostate cancer, Multidetector computerized tomography, bone scintigraphy.

SUMMARY Objectives: to describe the clinical and subclinical symptoms and evaluate the response after recurrent lymph node dissection of differentiated thyroid cancer patients after 131I treatment. Subjects: 50 differentiated thyroid cancer patients after 131I treatment, recurrence for the first time. Study methods: Retrospective and prospective description, data collection through patients’ medical records. Results: the mean age of the study patients was: 43.5 ± 12.6, the most common age is <55 years old with the rate of 80%, the female/ male ratio=3.5/1. The group of patients with Tg < 1 ng/ml accounted for the majority with 33/50 patients (66%). The median Tg before and after surgery was 2.02 ng/ml and 0.35 ng/ml, respectively. After surgery, response achieved in 98% of patients, mainly complete response and incomplete response in biochemical, accounted for 40%, 36%. Lymph node dissection reduced Tg in 78% of patients. Reccurent lymph nodes mainly observed in group IV, group III and group VI. The recurrence of lymph nodes was mainly in the central and cervical regions on the same side of the primary tumor. Conclusion: Surgery is the preferred first-line treatment for the reccurrent lymph node thyroid cancer patients. It changes response assessment, improve prognosis for reccurence patients after 131I treatment. Keywords: Differentiated thyroid cancer, response after recurrent lymph node dissection, Tg

SUMMARY Background: Osteoporosis is a disease that increases the risk of fractures. Evaluation of the Hounsfield Unit in the lumbar spine on computed tomography for any reason has the potential to predict bone density abnormalities that contribute to the warning of osteoporosis. Objective: The aim of this study was to evaluate the correlation between Hounsfield Units (HU) in Lumbar Spine (LS) and bone mineral density (BMD) measured by Dual-Energy X-Ray Absorptiometry (DEXA). Method: Retrospective and cross-sectional study of 150 patients comprised CT-DXA pairs within a 6-month period performed for any indication. Measure HU at lumbar vertebrae from L1 to L4. Calculate Spearman correlation coeffificient between the mean HU at lumbar vertebrae and the BMD values from DEXA scan. Using area under the ROC Curve (AUC) and finding cut-off of HU for diferentiating normal BMD and abnormal BMD, osteopenia and osteoporosis. Result: We noted correlations between the HU at LS and the BMD from DXA scan which is significant, the highest correlation at L2 (Spearman correlation coefficient = 0.68). At L2, normal BMD: ≥ 131 HU, osteopenia: 101 – 131 HU, osteoporosis: ≤ 131 HU, we also determined that threshold of 101 HU was more than 90 % sensitive, and a threshold of 171 HU was more than 90 % specific for distinguishing normal BMD. In addition, cut-off ≤ 132 HU was more than 90 % sensitive, and cut-off ≤ 62 HU was more than 90 % specific for distinguishing osteoporosis from osteopenia. Conclusion: The correlations between the HU at LS and the BMD from DXA scan is significant. Keyword : Osteoporosis, DEXA, HU at lumbar spine